The 2G UNic Platform accelerates stable CHO cell line development and boosts productivity across complex biologics workflows.
The 2G UNic Platform accelerates stable CHO cell line development and boosts productivity across complex biologics workflows.
The 2G UNic Platform supports high-performance biologics and viral vector manufacturing across mammalian and microbial systems. From rapid CHO cell line development to scalable yeast expression and producer or packaging cell line generation, the platform enables higher productivity, stable expression, and accelerated development timelines.
High-performance cell line development for antibodies, bispecifics, and complex biologics with enhanced productivity and stable expression.
Enhanced protein production in Pichia pastoris / Komagataella phaffii for enzymes, vaccine antigens, and recombinant proteins.
Rapid generation of stable, high-yield producer and packaging cell lines for scalable viral vector manufacturing.
High-performance cell line development for antibodies, bispecifics, and complex biologics with enhanced productivity and stable expression.
Enhanced protein production in Pichia pastoris / Komagataella phaffii for enzymes, vaccine antigens, and recombinant proteins.
Rapid generation of stable, high-yield producer and packaging cell lines for scalable viral vector manufacturing.
The 2G UNic Platform enables rapid generation of stable, high-producing CHO pools and clones for monoclonal antibodies, bispecifics, Fc-fusions, and other complex biologics. Designed to integrate seamlessly into existing workflows, the platform enhances productivity and expression stability without requiring changes to host systems, media, or development processes.
Across multiple CHO systems, including CHO-K1, CHO-S, DG44, and GS-knockout hosts, 2G UNic consistently delivers improved titers and stable long-term expression. By combining advanced vector technology with efficient transposon-mediated integration, the platform helps reduce screening burden, accelerate development timelines, and improve manufacturing efficiency.
Top clone achieved
Stronger pools increased the probability of finding exceptional clones.
The platform also supports challenging and difficult-to-express biologics. In published fed-batch studies, 2G UNic enabled titers exceeding 10 g/L for a multispecific antibody format, demonstrating robust performance even for highly complex molecules.
Fed-batch titer data (Peltret et al., 2024). 2G UNic vector technology enabled >10 g/L expression of a challenging multispecific antibody format.
Achieve 2–5× higher expression across multiple biologic formats, including difficult-to-express molecules and titers exceeding 10 g/L.
Reduce screening burden and accelerate progression from transfection to stable, high-producing CHO cell lines.
Maintain strong, consistent long-term expression to support reliable scale-up and manufacturing performance.
Achieve 2–5× higher expression across multiple biologic formats, including difficult-to-express molecules and titers exceeding 10 g/L.
Reduce screening burden and accelerate progression from transfection to stable, high-producing CHO cell lines.
Maintain strong, consistent long-term expression to support reliable scale-up and manufacturing performance.
The 2G UNic Platform also supports high-yield protein expression in yeast systems, including Pichia pastoris / Komagataella phaffii. By enhancing transcription, mRNA stability, and translation efficiency, the platform enables improved productivity across recombinant proteins, enzymes, and vaccine antigens.
Designed to integrate into existing microbial workflows, Yeast-2G UNic supports scalable protein production with consistent performance across both single-copy and multi-copy integration strategies.
Representative data from Pichia pastoris (Komagataella phaffii) expression studies comparing reference and Yeast-2G UNic constructs.
Single-copy clones
Multi-copy clones
Single-copy clones
Multi-copy clones
Yeast-2G UNic consistently increases protein yield across both single-copy and multi-copy integrations, demonstrating strong performance and scalability in microbial expression systems.
Increase protein productivity across microbial expression workflows.
Support robust expression in single-copy and multi-copy systems.
Enable reliable, high-yield yeast fermentation processes.
Increase protein productivity across microbial expression workflows.
Support robust expression in single-copy and multi-copy systems.
Enable reliable, high-yield yeast fermentation processes.
The 2G UNic Platform enables rapid generation of stable packaging and producer cell lines for viral vector manufacturing. By combining enhanced expression with transposase-mediated genomic integration, key viral components and payload genes can be incorporated within streamlined development workflows.
Stable, balanced expression of Rev, VSV-G, Gag-Pol, and the gene of interest (GOI) supports reliable vector output, improved process consistency, and reduced reliance on transient transfection systems.
Efficient transposase-mediated integration of helper genes and payload constructs.
Rapid generation of stable, high-performing viral vector production systems.
Support reliable, high-titer vector manufacturing with improved process consistency.
Efficient transposase-mediated integration of helper genes and payload constructs.
Rapid generation of stable, high-performing viral vector production systems.
Support reliable, high-titer vector manufacturing with improved process consistency.
The 2G UNic Platform is trusted by leading biopharma companies and CDMOs to accelerate cell line development, improve productivity, and support scalable manufacturing across biologics and viral vector workflows.
